Personal Development

Dr. Peter Attia — The Science and Art of Longevity (#661)

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“To understand what it means to live longer, you have to understand what ends life.”

— Dr. Peter Attia

Peter Attia, MD (@PeterAttiaMD), is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. He is the host of The Drive, one of the most popular podcasts covering the topics of health and medicine. 

Dr. Attia received his medical degree from the Stanford University School of Medicine and trained for five years at the Johns Hopkins Hospital in general surgery, where he was the recipient of several prestigious awards, including Resident of the Year. He spent two years at the National Institutes of Health as a surgical oncology fellow at the National Cancer Institute, where his research focused on immune-based therapies for melanoma.

His new book is Outlive: The Science and Art of Longevity (3/28).

Please enjoy!

Listen to the episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, Google Podcasts, Stitcher, Amazon Musicor on your favorite podcast platform. Watch the interview on YouTube here.

Brought to you by Wealthfront high-yield savings account, Helix Sleep premium mattresses, and Shopify global commerce platform providing tools to start, grow, market, and manage a retail business. 

#661: Dr. Peter Attia — The Science and Art of Longevity

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Want to hear Peter’s last time on the show? Listen to this conversation in which we discuss liquid biopsies, the four pillars of exercise someone seeking to improve their metabolic health should understand, methods for remedying modern posture problems, raising kids to be habitually active adults, the three levers of Peter’s nutritional framework, increasing scientific literacy, current pharmacological candidates for extending lifespan and healthspan, everything you ever wanted to know about zone two training, and much more.

#517: Dr. Peter Attia on Longevity Drugs, Alzheimer’s Disease, and the 3 Most Important Levers to Pull

What was your favorite quote or lesson from this episode? Please let me know in the comments.



  • Connect with Dr. Peter Attia:

Website | Twitter | Facebook | Instagram | YouTube


  • [07:00] How and why Peter’s muscle mass has increased significantly.
  • [18:48] Why the long wait for Outlive: The Science and Art of Longevity?
  • [23:19] Objective, strategy, and tactics.
  • [28:50] From Medicine 1.0 to Medicine 3.0.
  • [39:04] Randomized control trial results: guidelines, not gospel.
  • [43:21] Revisiting why and how one should increase their medical literacy.
  • [52:44] Avoiding scientific method misconceptions.
  • [55:43] Austin Bradford Hill.
  • [56:22] Observational study versus randomized control trial.
  • [1:00:09] Are sleep trackers downgrading the quality of our sleep?
  • [1:02:53] Under what conditions does Peter feel alcohol might be worth its downsides?
  • [1:06:47] Continuous glucose monitors (CGMs).
  • [1:18:24] Underutilized metrics and tools for expanding health and lifespan.
  • [1:25:01] Strength.
  • [1:33:11] Rucking around and finding out about VO2 max.
  • [1:38:32] Finding the zone two sweet spot.
  • [1:41:10] How skinning and rucking have upped my endurance.
  • [1:42:24] Rucking vs. weighted vests.
  • [1:46:39] Are neurodegenerative diseases preventable?
  • [1:51:47] Helping your doctor understand and embrace Medicine 3.0.
  • [1:53:47] How much is an ounce of prevention worth to you?
  • [1:58:23] Early cancer screening.
  • [2:06:33] Outlive chapters.
  • [2:08:46] The chapter on emotional health that almost didn’t make the book.
  • [2:10:16] Peter’s 47 affirmations.
  • [2:14:18] Parting thoughts.


“Despite what a lot of the epidemiology will tell people, alcohol is not good for you in any dose. It doesn’t mean we shouldn’t drink it at all, but let’s not delude ourselves into thinking it’s actually healthy at some low dose. It’s not.”
— Dr. Peter Attia

“My response to alcohol is, if I drink something that doesn’t taste incredible, I pour it out. I’m never going to tolerate a bad glass of wine, ever. It’s just not worth it.”
— Dr. Peter Attia

“Seven drinks in one day is very different than one drink a day for seven days. It’s the frequency and dose that defines the poison.”
— Dr. Peter Attia

“Not one to just clear the bar, I want to be considerably above the bar.”
— Dr. Peter Attia

“To understand what it means to live longer, you have to understand what ends life.”
— Dr. Peter Attia

“When I went to medical school, I didn’t learn a single thing about nutrition or exercise or sleep or stress management or emotional health. I learned a lot about pharmacology. And it’s tempting at this point to say, ‘Well, pharmacology is either good or bad.’ No, it’s both, right? Pharmacology is good and it’s really valuable, but over-indexing it is bad.”

— Dr. Peter Attia

“Sometimes more data is not always the answer.”

— Dr. Peter Attia

“Any measurement in isolation can be ridiculous and can be gamed. We shouldn’t ignore blood glucose any more than we should ignore body weight or body fat or body composition. We just have to understand that it’s one of many tools that we can look at.”

— Dr. Peter Attia

“To get into that top 2.5 percent of the population where you really start to see an enormous gap between you and everybody else in terms of lifespan, yeah, maybe only a quarter of the population has the potential to get there. But the point is everybody has the potential to be more fit than they are, outside of people who are already doing everything they can. So just going from being in the bottom 25 percent of the population to the 25th to 50th percentile of the population cuts your risk of all-cause mortality in half at any point in time. There’s nothing that compares to that.”

— Dr. Peter Attia


The Tim Ferriss Show is one of the most popular podcasts in the world with more than 900 million downloads. It has been selected for “Best of Apple Podcasts” three times, it is often the #1 interview podcast across all of Apple Podcasts, and it’s been ranked #1 out of 400,000+ podcasts on many occasions. To listen to any of the past episodes for free, check out this page.

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